A. Brugarolas, M. Gosálvez
Jan 12, 1980
Citations
2
Influential Citations
61
Citations
Quality indicators
Journal
The Lancet
Abstract
Thiazolidine-4-carboxylic acid (thioproline, "norgamem") a compound found to act on the cell membrane of tumour cells, causing reverse transformation to normal cells was investigated in patients with advanced cancer. Responses were obtained at several dose levels mainly in epidermoid carcinoma of the head and neck with pulmonary metastases. Histological studies showed involution and transformation into low-grade malignancies and disappearance of evidence of cancer.