H. Kazamatsuri
Sep 1, 1980
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Comprehensive psychiatry
Abstract
Abstract Based on the hypothesis that an enhanced dopaminergic activity in the basal ganglia may play an important role in tardive dyskinesia, the clinical efficacy of oxypertine, an indole derivative that has both dopamine-depleting activity and antipsychotic activity, for the treatment of tardive dyskinesia was studied in 10 patients for 3 wk. Oxypertine was shown to have marked antidyskinetic effect in 7 patients. This result appears to suggest a new approach to the symptomatic control of tardive dyskinesia with oxypertine. Also briefly reviewed were recent studies describing clinical efficacy of oxypertine for involuntary movements of tardive dyskinesia including a controlled trial where, unlike dimethylaminoethanol and sodium valproate, oxypertine was shown to be statistically significantly superior to placebo on both the AIMS scores and global ratings.