H. Lehmann
Apr 27, 1963
Citations
0
Influential Citations
25
Citations
Journal
British Medical Journal
Abstract
day before meals she is taking approximately one-fiftieth of the dose given the experimental rabbits. This laboratory experiment would not prove that cyclizine hydrochloride is a teratogenic compound in humans. It must be remembered that it is experimentally proved that cleft palate or skeletal defects can be produced by dietary deficiencies, hypervitaminosis A, anoxia, or cortisone. However, too literal a transference of the experimental results to man may be misleading; we may find many compounds which cause abnormalities when taken in 50 times the normal dose may be perfectly harmless when taken in normal or in a slightly excessive dosage.-I am, etc.,