M. Goldstein, Arthur F. Battista, T. Ohmoto
Feb 23, 1973
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102
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Journal
Science
Abstract
Either L-dopa, in combination with 1-α-methyldopa hydrazine (MK-486), or 1-(2''-pyrimidyl)-4-piperonylpiperazine, an agent that stimulates dopamine receptors, relieves surgically induced tremor in monkeys and concomitantly evokes involuntary movements. These results indicate that tremor and involuntary movements are associated with a common mechanism and that the activity of the dopamine receptors is involved in the regulation of these dysfunctions.