C. Thompson, P. Strong, D. Mikhailidis
Nov 1, 1996
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Journal
Nutrition Research
Abstract
Abstract We assessed the antilipolytic action of N-(1S, trans)-2-hydroxycyclopentyl] adenosine (GR 79236) in orally-treated large, old rats. The rats were gavaged with either GR 79236 (1mg/kg) or water (vehicle) and their plasma /serum biochemistry determined. GR 79236 significantly reduced plasma triacylglycerol and non-esterified fatty acid concentrations over a 5-day period (between group and within group comparison). There was no significant change in median blood glucose concentration when the GR 79236 and water-treated groups were compared. However, there was a significantly (p