Theodore L. Phillips, Todd H. Wasserman, J. Stetz
Mar 1, 1982
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Journal
International journal of radiation oncology, biology, physics
Abstract
This paper reviews the use of nitroimidazoles as radiosensitizers from their introduction into the clinical treatment of cancer with radiotherapy in 1974 to the present. Clinical trials with radiosensitizers are conventionally divided into 3 phases. Phase I included the initial escalation of drug dose and the establishment of dose limiting toxicity. The Phase II studies are directed toward specific tumor sites and histologies and genenerally involved a specific radiation regimen and a specific sensitizer drug regimen used in combination. The phase III studies are large scale investigations which are controlled and randomized. Radiosensitizer studies relevant to each phase are reviewed. (KRM)