J. Natale, J. Joseph, R. Pretzlaff
Aug 1, 2006
Citations
1
Influential Citations
28
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Quality indicators
Journal
Developmental Neuroscience
Abstract
In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.