C. Jimeno, Lidong Cao, P. Renaud
Jan 25, 2016
Citations
0
Influential Citations
20
Citations
Journal
The Journal of organic chemistry
Abstract
Trichloromethanesulfonyl chloride (CCl3SO2Cl), a commercially available reagent, has been found to perform efficiently in the α-chlorination of aldehydes, including its catalytic asymmetric version, under very mild reaction conditions. Under our reaction conditions, this compound outperforms typical chlorinating reagents for organic synthesis, facilitates workup and purification of the product, and minimizes the formation of toxic, chlorinated organic waste.