Honorine Lebraud, Céline Cano, B. Carbain
Feb 22, 2013
Citations
0
Influential Citations
10
Citations
Journal
Organic & biomolecular chemistry
Abstract
Purines protected at N-9 by p-methoxybenzyl are methylated or ethylated in 2,2,2-trifluoroethanol at N-7 by trimethyl- or triethyl-oxonium borofluorate, respectively. Subjecting the resulting cationic species to microwave irradiation releases an N(7)-methyl- or ethyl-purine. This one-pot procedure is an efficient regiospecific method applicable to diverse substrates.