Kannika La-ongthong, Teera Chantarojsiri, D. Soorukram
Mar 7, 2023
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Influential Citations
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Journal
Organic & biomolecular chemistry
Abstract
An efficient trifluoromethylation of 2-isocyanobiaryls was developed through the constant current electrolysis, employing sodium trifluoromethanesulfinate (CF3SO2Na) as the trifluoromethyl source. The method enabled the syntheses of a series of 6-(trifluoromethyl)phenanthridine derivatives in moderate to high yields under metal- and oxidant-free conditions. A gram-scale synthesis highlights the synthetic versatility of the reported protocol.