Xue-Hua Liu, Long Liu, Tianzeng Huang
Jun 10, 2021
Citations
1
Influential Citations
9
Citations
Journal
Organic letters
Abstract
The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.