Divyang M. Patel, H. Patel
Oct 25, 2019
Citations
1
Influential Citations
31
Citations
Journal
ACS Sustainable Chemistry & Engineering
Abstract
Nowadays, synthesis of novel nitrogen-bearing heterocyclic scaffolds is a challenging and demanding task as well. In our present work, we demonstrated a novel one-pot pseudo four-component reaction of 3,4-methylenedioxyaniline, N,N-dimethylbarbituric acid, and aryl/heteroaryl aldehyde for the regioselective construction of functionalized 6,8-dihydro-1'H,5H-spiro[[1,3]dioxolo[4,5-g]quinoline-7,5'-pyrimidine]-2',4',6' (3'H)-trione scaffolds using trimethyl glycine betaine based sustainable catalyst. The titled derivatives achieved through the formation of three new C-C bonds, one C-N bond, and generate two asymmetric carbon centers in final motif. Present protocol works efficiently, tolerate different substituents present in reactants, simple operational procedure, provide excellent reaction yield in short time, use of recyclable catalyst, up to 99.7% purity (HPLC) for the synthesized compounds, high diastereoselectivity (d.r.>50:1(syn:anti)), excellent Atom economy, Reaction mass efficiency, and Effective ...