A. Topolyan, D. A. Strizhevskaya, M. S. Slyundina
Dec 1, 2016
Citations
0
Influential Citations
5
Citations
Journal
Journal of Analytical Chemistry
Abstract
A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.