Kensuke Kiyokawa, Ikumi Noguchi, Takaya Nagata
Mar 27, 2023
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Journal
Organic letters
Abstract
We, herein, report on the bromocyanation of styrene derivatives with cyanogen bromide in the presence of tris(pentafluorophenyl)borane which functions as a Lewis acid catalyst that can effectively activate cyanogen bromide. This reaction proceeds through a stereospecific syn-addition. The protocol is operationally simple and provides practical access to β-bromonitriles.