Ting Zhao, André Boltjes, E. Herdtweck
Feb 1, 2013
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0
Influential Citations
42
Citations
Journal
Organic letters
Abstract
The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described in satisfactory to good yields. N-Unsubstituted α-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.