A. Feldstein, F. H. Chang, J. Kucharski
Mar 15, 1970
Citations
1
Influential Citations
67
Citations
Quality indicators
Journal
Life sciences
Abstract
Abstract Tryptophol, 5-hydroxytryptophol and 5-methoxytryptophol were found to induce sleep in mice. The onset of action was most rapid for tryptophol and 5-methoxytryptophol; 5-hydroxytryptophol had the slowest onset, probably due to difficulty of transport across the blood-brain barrier. Sleep times were shortest for tryptophol and 5-methoxytryptophol and longest for 5-hydroxytryptophol. It was suggested that the tryptophols or the corresponding aldehydes may play a role in physiological sleep mechanisms.