E. Smith, S. Sorota, Hyunjin Kim
Aug 1, 2010
Citations
0
Influential Citations
22
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK properties of leads will be described.