R. Swartz, F. Sidell
Jun 1, 1974
Citations
0
Influential Citations
22
Citations
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary Pralidoxime chloride is a quaternary ammonium used to reactivate organo-phosphate—inhibited cholinesterase. The drug is rapidly cleared from the plasma by renal tubular secretion, though the mechanism has not been specifically identified. Reduction of pralidoxime clearance rates and prolongation of the biologic half-life after thiamine administration as compared to those after PAH administration suggest that pralidoxime is secreted as an organic base. Furthermore, reduced excretion of pralidoxime under conditions of both urine alkalinization and urine acidification implicate an active reabsorption of pralidoxime not heretofore described.