A. Takeda, T. Hibino, A. Hoshino
1990
Citations
0
Influential Citations
5
Citations
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Journal
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
Abstract
To elucidate the tumor accumulation mechanism of 99mTc-DL-homocysteine (99mTc-Hcy), the role of mercaptalbumin, a carrier protein of 99mTc-Hcy in blood, was studied. 99mTc-Hcy bound to serum mercaptalbumin was carried to tumor tissue, efficiently adsorbed onto the cell surface, released from albumin, and taken up by the cells. An enlarged capillary permeability observed in tumor tissue played an important role in the transport process.