A. Haddow, W. Ross
May 26, 1956
Citations
0
Influential Citations
20
Citations
Journal
Nature
Abstract
IN the course of the preparation of various chloroethylamines which are potential tumour growth-inhibitors we have examined 2-chloroethyl methane-sulphonate (I, X = Cl; CB 1506) as a reagent for the direct conversion of an amino-group into a chloroethylamino-group under mild conditions. It occurred to us that amino-groups in biological systems might be chloroethylated in vivo by this compound. For this reason the methanesulphonate (I, X = Cl) was tested against a number of transplanted animal tumours.