G. Silvey
May 1, 1992
Citations
1
Influential Citations
7
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Two-dimensional and deuterium-induced, differential-isotope-shift NMR measurements have made it possible to assign completely all of the 1H and 13C resonances of potassium sucrose octasulfate (K8SOS) and thereby prove complete sulfation of the sugar moiety during synthesis. In addition, a comparison of the 13C NMR chemical shifts obtained for K8SOS and sucralfate made it possible to demonstrate that the sugar moiety in sucralfate is sucrose octasulfate (SOS8-). Finally, deuterium-induced, differential-isotope-shift and 13C NMR techniques were shown to be useful tools for detecting and characterizing carbon-containing impurities and hydrolysis products in solutions containing SOS8-.