S. Manta, Dimitra-Niki Gkaragkouni, Eleni Kaffesaki
Mar 12, 2014
Citations
1
Influential Citations
10
Citations
Quality indicators
Journal
Tetrahedron Letters
Abstract
Abstract A novel, two-step, facile route for the synthesis of pyrrolo[2,3- b ]quinoxalines via 2,3-dioxopyrroles, enhanced by microwave irradiation, is presented. The newly synthesized 2,3-dioxo-5-halophenyl pyrrolo precursors 4a – c as well as the non-aromatized ethyl 2-(4-halophenyl)-1-methyl-2,4-dihydro-1 H -pyrrolo[2,3- b ]quinoxaline-3-carboxylates 6a – c and the aromatized ethyl 2-(4-halophenyl)-1-methyl-1 H -pyrrolo[2,3- b ]quinoxaline-3-carboxylates 7a – c were evaluated for their antioxidant, cytostatic, and antiviral properties. Most of them proved to be potent hydroxyl radical scavengers and inhibited in vitro lipid peroxidation. The compounds showed moderate antiproliferative activity, while 6a inhibited vaccinia virus at an EC 50 value of 2 μM, and 4c and 6c inhibited Sindbis virus at EC 50 values of 4 μM.