Dahai Yu, Lei Wang, Q. Gu
Sep 1, 2007
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0
Influential Citations
11
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Journal
Process Biochemistry
Abstract
A two-step enzymatic resolution process for production of (R)- and (S)-glycidyl butyrate was investigated and the lipases were screened. The first step involved a hydrolysis of (R,S)-glycidyl butyrate catalyzed by porcine pancreatic lipase (S-favored) with an E of 21 for production of (R)glycidyl butyrate (13.2 mmol, 98% ee, 36% yield) under the optimal conditions (pH 7.4, 30 8C, 30 mg/ml CTAB). Then, the recovered (R)enriched glycidol(19.8 mmol,65%ee, 56% yield)wasused fortransesterification catalyzed byNovozym 435(R-favored)withanEof69toobtain (S)-glycidyl butyrate (15.1 mmol, 98% ee, 42% yield) under the optimum conditions (aW = 0.24, n-heptane, 80 min). # 2007 Elsevier Ltd. All rights reserved.