K. Kobayashi, T. Komatsu, Y. Yokoi
2011
Citations
0
Influential Citations
3
Citations
Journal
Helvetica Chimica Acta
Abstract
An efficient synthesis of 3-alkyl-3,4-dihydro-4-thioxobenzoquinazolin-2(1H)-ones 3 has been accomplished in two steps and in satisfactory yields from 1-bromo-2-fluorobenzenes 1. Thus, the reaction of 1-fluoro-2-lithiobenzenes, generated by the Br/Li exchange between 1 and BuLi, with alkyl isothiocyanates, gives N-alkyl-2-fluorobenzothioamides 2, which, in turn, react with a series of isocyanates in the presence of NaH to give the desired products 3.