G. Nixon, E. Buehler, R. Niewenhuis
Feb 1, 1972
Citations
1
Influential Citations
44
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract Trisodium nitrilotriacetate (Na 3 NTA) is currently being considered as a replacement for sodium tripolyphosphate (STP) as a builder in laundry detergent products. A chronic oral feeding study has been completed in which 0.03%, 0.15%, and 0.5% Na 3 NTA or 0.5% of the calcium chelate of NTA was fed to rats for up to 2 yr as part of the basic diet. The feeding of all test diets except 0.03% Na 3 NTA increased the incidence and severity of nephritis and nephrosis. An increased level of zinc was found in the bone of all test groups, but had no adverse effect on the general health of the rats. The feeding of 0.03% Na 3 NTA to rats as part of the basic diet for up to 2 yr elicited no apparent adverse effects on the physiologic or metabolic processes of these animals and is considered to be a no-effect level.