S. Krylov, Yu. M. Kosarev, T. A. Dezhinova
Apr 1, 1997
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Journal
Pharmaceutical Chemistry Journal
Abstract
3-Quinuclidinyl benzilate (3-QB), known as one of the most active cholinolytic agents, is an ester of quinuclidinol and diphenylglycolic acid. The acidic (diphenylglycol) and aminoalcohoI (quinuclidinol) parts of this compound markedly differ in their structures and immunological characteristics, that is, in sensitivity with respect to compounds conmining diphenylglycol or quinuclidinol groups [1]. The purpose of this work was to study the role of alcoholic and acidic parts of 3-QB in the pharmacological activity of this cholinolytic compound. We have attempted to solve this task by an immunological method. In a previous work [1] we have synthesized two types of 3-QB-conjugated antigens: 3-QB3-BSA-30 (in which 3-QB is attached to an antigen cartier, bovine serum albumin, via the nitrogen atom; haptenic epitope density 30) and 3-QBs-BSA-32 (in which 3-QB is attached to BSA via one of the benzene rings).