R. Taylor, C. Stubbs, L. Ellenbogen
May 1, 1970
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Deoxyfrenolicin, an analog of frenolicin, an antibiotic produced by Streptomyces fradiae , was shown to be a potent inhibitor of tyrosine hydroxylase. Kinetic studies indicated that inhibition was competitive with tyrosine, was increased by high concentrations of pteridine cofactor, and could not be reversed by Fe 2+ . When administered to rats at 50 mg/kg, deoxyfrenolicin significantly inhibited adrenal tyrosine hydroxylase activity. The naphthoquinone structure of deoxyfrenolicin represents a novel structure with tyrosine hydroxylase-inhibiting properties.