P. Erhardt, C. Woo, R. Gorczynski
Dec 1, 1982
Citations
0
Influential Citations
63
Citations
Journal
Journal of medicinal chemistry
Abstract
In an attempt to produce short-acting beta-adrenergic receptor blocking agents, we prepared several (aryloxy)propanolamines with ester functions incorporated into the nitrogen substituent. Many of these compounds exhibited a short duration of blocking activity after their continuous intravenous infusion for 40 min. However, their durations were found to increase considerably upon longer intravenous infusion.