S. Shelke, Yogesh Pawar, S. B. Pawar
Feb 5, 2009
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ChemInform
Abstract
A facile synthesis of title compounds has been carried out under ultrasound irradiation. The main advantages of the present procedure are shorter reaction time and higher yield. Products have been characterized by IR, PMR, CMR, GCMS study and screened for their antimicrobial Among the different functionalized chromones, 3-formylchromones occupy a unique position because they can be transformed into various heterocycles by interesting reactions with different nucleophiles. (1) 3-Formylchromone when treated with phenyl hydrazine gives 1-phenyl- 4-(2-hydroxy benzoyl) pyrazoles, (2) whereas substituted 3-formylchromone when treated with pyrrolidine (3) under reflux gives 1-(2-hydroxyaryl)-3-(pyrrolidin-1-yl)-prop-2-en-1-one. The enaminoketones (4) constitute an important class of synthon, which can be elaborated to a wide variety of heterocyclic compounds. The titled compound 1-(2-hydroxyaryl)-3-(pyrrolidin-1-yl)- prop-2-en-1-ones was utilized for the synthesis of pyrazoles (3) . Pyrrolidine containing compounds are versatile antidiabetic, antiobesity, (5) anticonvulsant (6) and antibacterial agents. (7)