M. S. Rao, M. Haritha, N. Chandrasekhar
May 23, 2015
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Influential Citations
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Quality indicators
Journal
Arabian Journal of Chemistry
Abstract
Abstract Designed as potential cytotoxic agents a series of 6-substituted 2,3-dihydro-1 H -pyrrolo[3,2,1- ij ]quinoline derivatives were synthesized by using a Bischler type reaction. The methodology involved the cyclodehydration of 2-(3,4-dihydroquinolin-1(2 H )-yl)-1-alkyl/aryl ethanones in the presence of p -TSA under ultrasound irradiation. A number of compounds were prepared using this methodology and tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Some of the compounds showed promising and selective cytotoxic effects toward leukemia cells.