A. Younesi, L. N. Sorotskaya, G. Krapivin
Jun 1, 2009
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0
Influential Citations
2
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Journal
Journal of The Chinese Chemical Society
Abstract
This paper describes a method of preparation of new 3,5'-dioxo-2'-phenyl-1,3-dihydrospiro[indene-2,4'-[1,3]oxazol]-1-yl acetate and its 5-chloro- and bromoderivatives as products of interaction of N-benzoylglycine (hippuric acid) with corresponding ortho-formylbenzoic acids. The reaction carried out in acetic anhydride media in the presence of piperidine as catalyst. The novel spirocompounds were purified by column chromatography from multicomponent reaction mixtures. The composition of the spiroproducts was confirmed by C, H, N element analysis. The structure was established by IR, MS, 1 H- and 13 C-NMR analysis including COSY 1 H- 13 C experiments.