S. Ng,, M. Drew, G. Mostafa
May 14, 2002
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Journal
ChemInform
Abstract
Action of HCl on 1-(8'-amino-α-naphthyl)-4-(8'-amino-a-naphthylamine)-1-azabuta-1,3-diene in aqueous methanol yields the mono hydrochloric acid salt of 1H-perimidine 1 as a dihydrate. A tentative mechanism for the reaction is proposed. The X-ray crystal structure of the salt has been determined. Neutralisation of an aqueous solution of the hydrochloride salt by a base generates 1, which has antitumor activities, in the free state.