M. Deiana, J. Jamroskovic, Ikenna Obi
Oct 29, 2020
Citations
0
Influential Citations
5
Citations
Journal
Chemical communications
Abstract
Phen-DC3 is among the most commonly used G-quadruplex (G4)-stabilizers in vitro and in cells. Here, we show that the G4-interactive binding interactions enable one to tune the optical properties of Phen-DC3 allowing the detection of G4 structures in cancer cells. This work opens up new directions for the use of Phen-DC3 as a selective G4 fluorescent reporter.