B. Skrede, Rune Blomhoff, G. Mælandsmo
Apr 1, 1992
Citations
2
Influential Citations
23
Citations
Quality indicators
Journal
European Journal of Clinical Investigation
Abstract
Abstract. Retinoids have been successfully used in the treatment of some forms of leukaemia, suggesting that such cells have an efficient uptake mechanism for circulating retinoids. Therefore, we have studied the uptake of lipoprotein‐associated retinyl esters in human leukocytes in vivo. After an oral load of 100 μmol retinyl palmitate (30000 retinol equivalents) per square meter given to healthy adults, the concentration of retinoids in circulating leukocytes was determined. A peak was measured after 5 h, which coincided with a peak of retinyl esters in plasma.