K. U. Prasad, M. Iqbal, D. Urry
Jan 12, 2009
Citations
2
Influential Citations
57
Citations
Journal
International journal of peptide and protein research
Abstract
The coupling of Boc-Val-OH to either H-Pro-OBzl or H-Pro-Gly-Val-Gly-OBzl by the mixed anhydride method leads to the formation of a urethane by-product in yields of 40-60%. This side reaction can be suppressed by the addition of HOBt to the reaction mixture before the amino component is added. This results in a substantially increased yield of the desired peptide.