P. Ellinger, G. Fraenkel, M. Abdel Kader
1947
Citations
0
Influential Citations
18
Citations
Journal
The Biochemical journal
Abstract
nicotinamide methochloride, pyridine, pyri- dine.3-sulphonic acid, 6-methylnicotinic acid, 3-acetyl-pyridine, 3-aminopyridine, quinolinic acid, picolinic acid, isonicotinic acid, hexahydronicotinic acid, nicotinonitrile, pyrazine 2:3-dicarboxylic acids, thiazole-5- carboxylic nicotinethylamide and -diethylamide, ethyl nicotinate, quinolinic acid, and pyrazine mono- and 2:3-dicarboxylic acids are active against pellagra. a-Picoline, trigonelline, and 3-aminopyridine are inactive, whilst ,B-picoline, 2:6-dimethylpyridine-3:5-dicarboxylic acid, and pyridine-3:5-dicarboxylic acid are of doubtful activity. Nicotinamide methochloride has been found to be formed in the mammalian body after administration of nicotinic acid, nicotinamide or nicotindiethylamide (Najjar & Holt, 1941; Ellinger & Coulson, 1944). The former authors found no increased nicotinamide methochloride elimination after administration of trigonelline, 2:6-di-methylpyridine-3:5-dicarboxylic acid, quinolinic acid, pyri- dine-3:5-dicarboxylic acid and pyrazine mono- and 2:3-dicarboxylic acids.