A. Gakh, S. Zlotin, P. G. Kislitsin
Jun 1, 2006
Citations
0
Influential Citations
8
Citations
Journal
Heterocycles
Abstract
A convenient synthesis of nitro-free 4,6-disubstituted 3-aminobenzothiophenes, their S-oxides and S,S-dioxides based on the available 2,4,6-trinitrobenzamide has been developed. The synthesis entails stepwise nucleophilic substitution of all nitro groups in the starting compound by S-, N-, and O-nucleophiles followed by Thorpe-Ziegler cyclization.