N. Sahoo, M. Sahu, .. V.Alagarsamy
2015
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Influential Citations
4
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Abstract
Imatinib is chemically a N-(4-methyl-3-{[4-(pyridin-3-yl) pyrimidin-2-yl] amino} phenyl)-4-[(4-methylpiperazin-1-yl) methyl] benzamide. It is an anti neoplastic agent used to treat chronic myelogenous leukemia. Imatinib is used to treat Chronic Myelogenous Leukemia (CML), Gastrointestinal Stromal Tumors (GISTs) and a number of other malignancies. imatinib mesylate was effective in patients with systemic mastocytosis, including those who had the D816V mutation in c-Kit. However, since imatinib binds to tyrosine kinases when they are in the inactive configuration and the D816V mutant of c-Kit is constitutively active, imatinib does not inhibit the kinase activity of the D816V mutant of c-Kit.