M. Kitahara, Masaaki Asano, H. Naganawa
Jun 1, 1978
Citations
1
Influential Citations
111
Citations
Quality indicators
Journal
The Journal of antibiotics
Abstract
brane, had important effects on cellular functions1^. These inhibitors included esterastin which inhibited esterase and suppressed immune responses45 (as well as) ebelactones which inhibited esterase but enhanced immuneresponses55. Continued screening for esterase inhibitors has resulted in the discovery of another inhibitor which we have named valilactone. Valilactone has no effect on immune responses. In this paper, we report on the isolation and characterization of valilactone. In the screening study, culture filtrates of many strains of various species of soil actinomycetes showed the activity to inhibit esterase. Wehave isolated a new inhibitor from the strain MG147CF2. This strain, closely related to Strepto-