M. Halushka, Linda P. Walker, P. Halushka
Jan 1, 2003
Citations
13
Influential Citations
257
Citations
Quality indicators
Journal
Clinical Pharmacology & Therapeutics
Abstract
A critical clinical application of the Human Genome Project is to identify functional variation in genes related to disease or responses to xenobiotics. This study moved toward that goal by combining polymorphism detection with functional assays for the therapeutic target gene cyclooxygenase 1 (COX‐1). Cyclooxygenase 1 (prostaglandin endoperoxide G/H synthase [PTGS1]) catalyzes the metabolism of arachidonic acid to prostaglandin H2, which is subsequently metabolized to thromboxane A2.