Keith Smith, G. El‐Hiti, Amany S. Hegazy
Sep 1, 2009
Citations
0
Influential Citations
11
Citations
Journal
Synlett
Abstract
Directed lithiation of N-(2-methoxybenzyl)pivalamide with two mole equivalents of t-BuLi in anhydrous THF at -78 ˚C followed by reactions with various electrophiles gave ring substitution, but ortho to the methoxy group rather than ortho to the pivaloylaminomethyl group, which was unexpected in view of earlier results reported with n-BuLi.