S. Sharma, Manoranjan Kumar, Vishal Kumar
Sep 4, 2013
Citations
0
Influential Citations
42
Citations
Journal
Tetrahedron Letters
Abstract
Vasicine, a quinazoline alkaloid isolated from Adhatoda vasica, has been employed as an organocatalyst for direct C–H arylation of unactivated arenes with aryl iodides/bromides without the assistance of any transition metal catalyst. A number of sensitive functional groups such as methyl, methoxy, O-benzyl, acetyl, and amino were well tolerated under present reaction conditions. Mechanistic investigation supported the involvement of radical intermediates.