M. Aga, B. Kumar, A. Rouf
Apr 16, 2014
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The first report of natural l -vasicine as tridentate chiral ligand for the enantioselective addition of diethylzinc to a variety of aliphatic and aromatic aldehydes is described. The ligand generates R -isomer of the secondary alcohols upto 98% ee. The quinazoline structure possibly imparts rigidity to the ligand and hence, consistently high enantioselectivity. The importance of the quinazoline ring was also supported by the reaction with other related ligands, partially lacking the structural features, thus resulting in poor enantioselectivity.