A. Nadeem, Bashir Ahmed, Hira Shahzad
Nov 13, 2021
Citations
0
Influential Citations
6
Citations
Journal
Pharmacognosy Journal
Abstract
Cure of microbial ailments via plant extracts is in practice for centuries1 deals with infectious diseases because of their antibiotic and antioxidant potential. Verbascum thapsus also known as common mullein is utilized as traditional medicine and tea rich in antioxidants and antibacterial plants for long time1,2. More than one hundred accepted names are given to large genus Verbascum belonging from Scrophulariaceae family in plant databases3. Leaves and flowers of V. Thapsus have expectorant and anti-inflammatory potential in herbal medicines4. V. thapsus reduces the severity of respiratory conditions including bronchitis and asthma along with reported effectiveness against haemorrhoids, fungal infections, and diarrhea5. Yet, the detailed phytochemical spectrum in versatile solvents remains relatively understudied. Plants from Verbascum genus have exhibited inhibitory activity against murine lymphocytic leukaemia, several strains of influenza viruses, Trichomonas vaginalis, etc.2. Plants of Verbascum species also have potential anticarcinogenic properties5. Verbascum Thapsus has been used as herbal treatment of several disorders, but no FDA approved drug is yet available. Prominent medicinal uses include treatment for Parkinson’s disease, diabetes, bronchitis, asthma, joints and stomach pain, and skin issues etc3. Flower extracts of V. Thapsus also show promising concentrations of Terpenoids. Iridoid glycosides, Lignan glycosides, phenylethanoid glycosides, sterones and saponins etc3,6. Verbascum thapsus is extensively grown in temperate areas of Pakistan5 and its medicinal importance prompted us to study it comprehensively. The phytochemistry of Verbascum thapsus is usually studied in a single solvent i.e., methanol, in the past decade7 and not a single study discusses it in all five range of solvents. Therefore, in continuation of prior studies, the present study aims to explore multiple aspects i.e., phytochemical analyses of Verbascum thapsus and quantitative/qualitative investigations via GCMS and its antibacterial activities in five different solvents (Figure 1).