Catherine Mckay, T. J. Simpson, C. Willis
2000
Citations
0
Influential Citations
24
Citations
Journal
Chemical Communications
Abstract
The total synthesis of pseudomonic acid C is described using an approach which gives access to analogues and putative biosynthetic precursors; the key step is installation of the C7 side-chain via alkylation of a trisubstituted δ-lactone with complete stereocontrol and in 85% yield under conditions which avoid the possible competing elimination of a protected hydroxy group β to the carbonyl.