Xisheng Wang, T. Mei, jin-quan yu
May 12, 2009
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0
Influential Citations
299
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
Pd(OTf)(2) x 2 H(2)O-catalyzed ortho-fluorination of triflamide-protected benzylamines is reported. The use of N-fluoro-2,4,6-trimethylpyridinium triflate as the F(+) source and NMP as a promoter is crucial for this reaction. The conversion of triflamide into a wide range of synthetically useful functional groups makes this fluorination protocol broadly applicable in medicinal chemistry and synthesis.