V. Y. Mortikov, Y. Litvinov, A. A. Shestopalov
Nov 1, 2008
Citations
0
Influential Citations
26
Citations
Journal
Russian Chemical Bulletin
Abstract
A versatile method for the synthesis of 2′-amino-1,2-dihydrospiro[(3H)-indole-3,4′-(4′H)-pyran]-2-ones has been suggested consisting in the three-component reaction of isatins, cyanoacetic acid derivatives, and α-methylenecarbonyl compounds (β-dicarbonyl compounds, activated phenols, and OH-substituted heterocycles) in ethanol in the presence of triethylamine as a catalyst. The reaction proceeds selectively to form spiro[(3H)-indole-3,4′-(4′H)-pyrans].