R. Hertz, M. Lipsett, R. H. Moy
Aug 1, 1960
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Influential Citations
83
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Quality indicators
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Cancer research
Abstract
An alkaloid, Vincaleukoblastine, has suppressed tumor growth and activity in five of eight women with methotrexate-resistant, metastatic trophoblastic disease. In three of these patients the urinary gonadotropin excretion reached normal levels, and in two other patients there was a decrease in pulmonary metastases. Reversible toxic effects have included bone marrow depression with severe leukopenia, alopecia, and neurotoxicity.