Chao Tian, Qiyue Wang, Xueqi Wang
Sep 19, 2019
Citations
0
Influential Citations
31
Citations
Journal
The Journal of organic chemistry
Abstract
A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using the low-costing and stable Langlois reagent (CF3SO2Na) as the "CF3" source has been developed. In contrary to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, the mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives.