Lingchong Yu, Jiwei Gu, Shu Zhang
Mar 24, 2017
Citations
0
Influential Citations
37
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient and synthetically convenient method for the synthesis of 3,3-difluoro-2-oxindole through a visible-light-induced photoredox difluoromethylation-amidation is described. The process can generate a broad range of difluorooxindoles using bromodifluoroacetate and broadly available free anilines. The wide range of substrate tolerance and mild reaction conditions make this transformation a highly valuable method in applications for drug discovery and development.